Italy's reigning Olympic champion was second to Corinne Suter in yesterday's race after narrowly avoiding crashing at the compression jump, and she beat the Swiss by 0.24s to record her first win since last December's St Moritz Super G.
Breezy Johnson was three-hundredths of a second further back in third as the American scored her second career World Cup podium in the space of 24 hours.
Plenty of skiers showed good speed at the top, but Goggia was in a class of her own on the bottom half.
Johnson was a full three-quarters of a second up at the second time check but lost time lower down and had to settle for another third place.
The famous OK course was tweaked slightly to avoid a repeat of the high number of crashes on the right-hand turn after the compression jump, including a lucky escape for 2017 Super G world champion Nicole Schmidhofer, in Friday's race.
Schmidhofer is out for the rest of the season after rupturing knee ligaments with last season's overall Crystal Globe winner Federica Brignone and Alice McKennis-Duran also missing today's race after falls yesterday.
Vlhova remains on 425 points ahead of Gisin on 298 and Shiffrin on 275.
After two downhills, the women end their long weekend in the French Alps with a Super G on Sunday.