Marta Bassino won the first FIS Alpine Ski World Cup race of the season in Soelden, Austria on Saturday (17 October).
Brignone won last year's giant slalom and overall World Cup series titles.
“I was skiing very well in training, so I tried to ski as in training also today,” Bassino said in the finish zone, “it came naturally, and that’s why I’m so proud.”
With fog and snowfall making for poor visibility, particularly in the first run, it was the two Italians who adapted best.
Bassino led by a massive 0.58s after the first descent before holding on for victory, with Vlhova clocking the quickest time on run two to rise from 10th to third.
It was a distinctly quiet affair in Austria's Ötztal Valley with just 200 guests watching the action rather than the 15,000-crowd with cowbells usually in attendance.
Italians dominate Soelden curtain raiser
Bassino and Brignone were one and two after the first run and that's how they finished.
Norway's Mina Fuerst Holtmann was the only other skier within a second of Bassino on the first run, but was only 13th on her second descent and finished fifth.
She was tied for fourth after the first run, 1.18s behind Bassino, but struggled on the second to finish down in 12th place.
Earlier this week, she told Olympic Channel about her preparations for the new season with her coaches unable to enter New Zealand during lockdown.
Switzerland's Michelle Gisin clocked the same as Robinson on the first run and finished fourth on the day, 0.17s outside the podium spots.
It was a day to celebrate for fans everywhere, when winner Bassino was asked how she feels now that skiing is finally back, she said, "fantastic, finally the season starts and it’s amazing for the entire world."
The men's opener comes tomorrow, Sunday 18th October.