The two half-marathon world record holders took victory in the New York City Marathon on another day of Kenyan superiority.
Joyciline Jepkosgei powered clear of four-time winner Mary Keitany to take victory on her marathon debut.
Kipchoge was the first to greet Kamworor at the finish line, three weeks after his historic sub-two hour run in Vienna.
"From the start of the race, I was feeling okay. I was comfortable. I prepared very well to run this marathon." - Geoffrey Kamworor in a statement after his New York City marathon victory
Daniel Romanchuk and Manuela Schaer continued their dominance of the wheelchair events, crossing the line first in Central Park to retain their titles.
Kamworor keeps up Kenyan dominance
The men's race was billed as a clash between world champion Desisa and 2017 winner Kamworor.
In perfect marathon-running conditions, last year's runner-up Shura Kitata attacked 11km into the race with Desisa quitting moments later as the four-week turnaround from taking gold in Doha proved too great a hurdle to overcome.
Kitata was back in the lead group at halfway with Brett Robinson then taking his turn to try and go clear at the front.
The Australian did not last too long at the head of affairs, but his burst did thin out the pack to eight although that swelled to 12 again as the pace slowed.
Tola really pushed the pace inside the last 8km with Kitata losing touch, perhaps paying for his earlier exertions.
But then the Kenyan pair took over with 5km to go and quickly left their East African neighbours battling for third place.
And having broken the Ethiopians, Kamworor wasted little time in putting the race to bed as he surged clear of his countryman to win in 2:08:13.
Korir made it a Kenya one-two in 2:08:36 with Bekele Gebre just two seconds behind as he smashed his personal best.
Tola was fourth ahead of Kitata with Jared Ward the first American home in sixth place.
Jepkosgei's dream debut
The women set off half an hour before the men and Des Linden gave the home crowd reason to cheer as she attacked after 13km.
The 2018 Boston Marathon winner was caught just before halfway by defending champion Keitany, Ruti Aga, Jepkosgei and Nancy Kiprop.
Five soon became three as Linden and Kiprop were left behind.
At 30km, Aga started to struggle as the two Kenyans - the veteran Keitany and marathon debutant Jepkosgei - raised the tempo.
It was a captivating duel as the slight figure of Keitany ran stride for stride with her more powerfully-built compatriot separated by up to five metres laterally on the road.
With 7km to go, the 'Queen of New York' showed the first sign of weakness as she slotted in behind her rival.
And soon, Jepkosgei started to move clear as she made what proved to be a decisive break for victory.
Cheered on by large crowds in Central Park, the 25-year-old crossed the line in 2:22:38 just seven seconds outside Margaret Okayo's course record from 2003.
Keitany was second, almost a minute behind, with Aga third in 2:25:51.
Kiprop took fourth just ahead of 42-year-old Australian Sinead Diver with Linden rounding out the top six.
"My strategy I had planned was to finish the race strong. But in the last kilometres, I saw that I was capable of winning." - Joyciline Jepkosgei in a statement after her New York City marathon win
Romanchuk and Schaer win again
Three weeks after winning in Chicago, Daniel Romanchuk became the first American man to retain the wheelchair title in New York.
The 21-year-old crossed the line in 1:37:24, just ahead of Switzerland's Marcel Hug.
There's no rest for Romanchuk as he heads to the World Para Athletics Championships in Dubai where he will try to take Hug's titles in the 800m, 1500m and 5000m T54 events.
Manuela Schaer has been even more dominant in recent times with the Swiss completing a hat-trick of wins in the women's event.
The 34-year-old took victory in 1:44:20 to extend her unbeaten record to nine marathons.
Cancer survivor Randall breaks three hours
The former cross-country skier didn't just beat that barrier, she smashed through it as she clocked 2:55:12.
She seemed to get stronger as the race went on, going through the second half of the race three minutes faster than the first.
The 36-year-old announced she was cancer-free in March, nine months after being diagnosed with cancer.