The in-form Swiss skier triumphed in Garmisch ahead of 22-year-old Norwegian Lie, with Marie-Michele Gagnon of Canada in third.
On the legendary Kandahar slope, the Sochi 2014 downhill bronze medallist from Switzerland clocked 1:15.70 to finish 0.68 seconds ahead of two-time junior world champion Kajsa Vickhoff Lie of Norway.
Canada's Marie-Michele Gagnon completed the podium (+0.93 seconds) after starting with the bib No. 29.
Downhill Olympic champion Sofia Goggia came in fourth, exactly one second off the pace.
Gut-Behrami, who was the last woman to win three back-to-back Super G races from December 2016 to January 2017, made the podium for the fourth consecutive time this season and is one of the women to watch ahead of next week's world championships in Cortina.
It was a 15th Super G win in World Cup skiing for the 29-year-old Swiss speed-merchant, who's fourth in the all-time women's Super G victory list behind Lindsey Vonn (28), Renate Goetschl (17) and Katja Seizinger (16).
"It is super cool to be this fast again. I am happy that my confidence is back," Lara Gut-Behrami said after the race.
PyeongChang 2018 gold medallist Ester Ledecka finished in sixth, 0.03 seconds ahead of Super G globe holder Corinne Suter.
Petra Vlhova ended in joint-tenth with Tiffany Gauthier to earn 26 points and extend her overall World Cup lead over Switzerland's Michelle Gisin (909 vs 783 points).
The Olympic combined champion decided to opt out from the events in Garmisch to focus on Cortina 2021 preparations.
Gut Behrami sits now in second in the standings (847 points) and now has the chance to close the gap or even overtake the Slovakian.
Today's Super G replaced the scheduled downhill race. The event was cancelled due to the difficult weather conditions in the Bavarian resort and will take place in Val di Fassa on 26 February.
Tomorrow (Sunday 31 January) Garmisch-Partnekirchen will host another Super G, the last World Cup event ahead of the world championships in Cortina starting next Sunday (7 February).
On this course the men will race a Super G and a downhill next weekend (5-6 February).