Lindsey Vonn will miss the Lake Louise downhill and Super-G races after injuring her knee.
The Vancouver 2010 Olympic champion, who was due to compete in her first World Cup of the season in the Canadian resort next week, crashed while training for the Super-G.
However, the American, who has suffered from serious injuries throughout her career, says the latest will not require surgery.
Vonn is chasing Ingemar Stenmark's all-time World Cup wins record of 86.
The 33-year-old, who has announced her retirement from competitive skiing after this season, currently sits on 82.
Competing at Lake Louise would have given her the chance to move to 85 wins, with two downhills and a Super-G scheduled.
Vonn had previously said she wouldn't retire before surpassing Stenmark, although she changed her mind ahead of this season.
It is a missed opportunity for Vonn to win on one of her most successful slopes.
The three-time Olympic medallist has claimed 18 of her 82 career World Cup victories in the Alberta resort, including winning all three races there in 2012, 2013, and 2016.
If her knee recovers in time, there is a Super-G World Cup meet in St. Moritz, Switzerland, on 8 December for Vonn to add to her wins total before super combined, downhill, and Super-G races in Val d'Isere, France, a week later.