Goggia set the pace early, going all-out in bib number 5, and no-one could better her time.
The reigning downhill Olympic champion clocked 1:24.06 to claim her sixth downhill crown and move into a clear lead at the top of the season standings in this discipline.
Local hero Tamara Tippler came closest to Goggia, taking second place +0.96 off the top mark.
The Austrian Super-G specialist jumped up on her first World Cup downhill podium ever racing on home snow.
"I was really focussed on the things I had to do," Goggia said post-race.
"In Val d'Isere I knew I could get (Does air quote marks) easily on the podium but here I thought that maybe the giant slalom skiers could have won.
"I had just one strategy and that was to get out of the start gate and bring intensity and energy in my skiing, and I think I made it.
"Now the red bib is mine ya, but it's the same, we keep on going, race by race. You know how it works!"
23-year-old Laura Pirovano fell to the snow in tears after her best run ever left her in fifth place (+1.15).
And there was a tie for sixth place as Slovakian Ilka Stuhec and Corinne Suter both finished +1.16 off the pace.
Suter came into this race joint-top of the downhill standings with Goggia, the Swiss skier winning the first downhill of the season before Christmas.
Overall World Cup leader Petra Vlhova finished in 12th in this first speed race of 2021.
Goggia tops downhill standings
Goggia skis clear at the top of the standings with this win on 280 points, with Corinne Suter second and just ahead of Breezy Johnson who picked up 60 points for her third-place finish.
Vlhova has extended her overall lead on Michelle Gisin (20th on the day, 637 vs 498 points), with Goggia in third position (498).
The speed weekend in St Anton will finish on Sunday (10 January) with the Super G starting at 11:30 am CET.