France's two-time world champion came from behind to seal her 14th career win. Lara Gut-Behrami finished second, with Marta Bassino completing the podium.
The 31-year-old Frenchwoman was fifth after the first run, then with an aggressive display in the second round clocked the fastest combined time (2:11.38) to finish 0.27 seconds ahead of Switzerland's Lara Gut-Behrami.
Marta Bassino of Italy completed the podium after ending a run of four consecutive wins in the discipline.
Mikaela Shiffrin was fourth, 1.08 seconds off the pace. The American recorded the second-best time in the first run, but failed to clinch her fifth podium this season.
This was the 14th career win for Worley, who previously finished on the podium in Courchevel and Kranjska Gora.
The two-time GS globe winner has joined Anita Wachter, Lise-Marie Morerod, Tina Maze, and Viktoria Rebensburg in joint-third place in the all-time list of the most successful women in the discipline.
The last time she topped the podium in a World Cup event was in October 2018 in Soelden.
"I'm so happy, a part of me was saying, 'yes, you have it in you and you can still do it...' Another part was like, 'maybe you're over for a win...," Worley told FIS after the race.
"Today I knew it was going to be a big, big fight, I just wanted to take all the risks, to not have any regrets, and see how it could go
"I never thought about winning, it was just about putting everything that I had on the slope."
The two-time GS world champion features in our original series Cirque Blanc, which is following the French women's team throughout this season, giving exclusive behind-the-scenes insight ahead of the Beijing 2022 Winter Olympics.
Michelle Gisin, who led after the first run, made a mistake in the final part and settled for 6th.
However, the reigning combined Olympic champion managed to close the gap from overall leader Petra Vlhova to 100 points.
The Slovakian looked tired on the steep and icy course of the 'Erta' and finished only in 12th place.
Following a disappointing second run, overall title holder Federica Brignone dropped from the third to the eighth position, while fellow Italian Sofia Goggia put down a storming second round to finish seventh.
The next women's giant slalom will take place in Jasna, Slovakia, after the World Championships in Cortina d'Ampezzo (Feb 8-21).